BDBM738340 2,6-difluoro-N- (2-methoxy-5- (4-(8-((E)-4- oxopent-2- enoyl)-3,8- diazabicyclo [3.2.1]octan-3- yl)quinazolin-6- yl)pyridin-3-yl) benzene- sulfonamide::US20250145589, Example 145

SMILES COc1ncc(-c2ccc3ncnc(N4CC5CCC(C4)N5C(=O)/C=C/C(C)=O)c3c2)cc1NS(=O)(=O)c1c(F)cccc1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 738340   

LigandPNGBDBM738340(2,6-difluoro-N- (2-methoxy-5- (4-(8-((E)-4- oxopen...)
Affinity DataIC50: 0.440nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kα with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

LigandPNGBDBM738340(2,6-difluoro-N- (2-methoxy-5- (4-(8-((E)-4- oxopen...)
Affinity DataIC50: 23.8nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kδ with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandPNGBDBM738340(2,6-difluoro-N- (2-methoxy-5- (4-(8-((E)-4- oxopen...)
Affinity DataIC50: 200nMAssay Description:The HTRF KRASG12C/SOS1 Binding Assay was used to measure the interaction between KRASG12C and SOS1 proteins, and evaluate the enzymatic activity of c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent