BDBM738349 (S,E)-2,4,6- trifluoro-N-(2- methoxy-5-(4- (2-methyl-4-(4- oxopent-2- enoyl)piperazin- 1-yl)quinazolin- 6-yl)pyridin-3- yl)benzene- sulfonamide::US20250145589, Example 154

SMILES COc1ncc(-c2ccc3ncnc(N4CCN(C(=O)/C=C/C(C)=O)C[C@@H]4C)c3c2)cc1NS(=O)(=O)c1c(F)cc(F)cc1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 738349   

LigandPNGBDBM738349((S,E)-2,4,6- trifluoro-N-(2- methoxy-5-(4- (2-meth...)
Affinity DataIC50: 0.540nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kα with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM738349((S,E)-2,4,6- trifluoro-N-(2- methoxy-5-(4- (2-meth...)
Affinity DataIC50: 13.8nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kδ with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM738349((S,E)-2,4,6- trifluoro-N-(2- methoxy-5-(4- (2-meth...)
Affinity DataIC50: 183nMAssay Description:The HTRF KRASG12C/SOS1 Binding Assay was used to measure the interaction between KRASG12C and SOS1 proteins, and evaluate the enzymatic activity of c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent