BDBM738350 2,4,6-trifluoro- N-(2-methoxy- 5-(4-(8-((E)-4- oxopent-2- enoyl))-3,8- diazabicyclo [3.2.1]octyl-3- yl)quinazolin-6- yl)pyridin-3-yl) benzene- sulfonamide::US20250145589, Example 155

SMILES COc1ncc(-c2ccc3ncnc(N4CC5CCC(C4)N5C(=O)/C=C/C(C)=O)c3c2)cc1NS(=O)(=O)c1c(F)cc(F)cc1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 738350   

LigandPNGBDBM738350(2,4,6-trifluoro- N-(2-methoxy- 5-(4-(8-((E)-4- oxo...)
Affinity DataIC50: 0.300nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kα with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM738350(2,4,6-trifluoro- N-(2-methoxy- 5-(4-(8-((E)-4- oxo...)
Affinity DataIC50: 53.1nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kδ with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM738350(2,4,6-trifluoro- N-(2-methoxy- 5-(4-(8-((E)-4- oxo...)
Affinity DataIC50: 462nMAssay Description:The HTRF KRASG12C/SOS1 Binding Assay was used to measure the interaction between KRASG12C and SOS1 proteins, and evaluate the enzymatic activity of c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent