BDBM738360 (E)-5-chloro- N-(2-methoxy- 5-(4-(4- (4-oxopent-2- enoyl) piperazin-1-yl) quinazolin-6- yl)pyridin-3- yl)thiazole-2- sulfonamide::US20250145589, Example 165

SMILES COc1ncc(-c2ccc3ncnc(N4CCN(C(=O)/C=C/C(C)=O)CC4)c3c2)cc1NS(=O)(=O)c1ncc(Cl)s1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 738360   

LigandPNGBDBM738360((E)-5-chloro- N-(2-methoxy- 5-(4-(4- (4-oxopent-2-...)
Affinity DataIC50: 1.20nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kα with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM738360((E)-5-chloro- N-(2-methoxy- 5-(4-(4- (4-oxopent-2-...)
Affinity DataIC50: 12nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kδ with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM738360((E)-5-chloro- N-(2-methoxy- 5-(4-(4- (4-oxopent-2-...)
Affinity DataIC50: 362nMAssay Description:The HTRF KRASG12C/SOS1 Binding Assay was used to measure the interaction between KRASG12C and SOS1 proteins, and evaluate the enzymatic activity of c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent