BDBM738374 (E)-4-(4-(6-(5- ((2,4- difluorophenyl) sulfonamido)- 6-methoxy- pyridin-3-yl) quinazolin-4- yl)piperazin-1- yl)-N-methyl- 4-oxobut-2- enamide::US20250145589, Example 179

SMILES CNC(=O)/C=C/C(=O)N1CCN(c2ncnc3ccc(-c4cnc(OC)c(NS(=O)(=O)c5ccc(F)cc5F)c4)cc23)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 738374   

LigandPNGBDBM738374((E)-4-(4-(6-(5- ((2,4- difluorophenyl) sulfonamido...)
Affinity DataIC50: 0.370nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kα with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM738374((E)-4-(4-(6-(5- ((2,4- difluorophenyl) sulfonamido...)
Affinity DataIC50: 147nMAssay Description:The HTRF KRASG12C/SOS1 Binding Assay was used to measure the interaction between KRASG12C and SOS1 proteins, and evaluate the enzymatic activity of c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent