BDBM738376 methyl (E)-3- ((2,4-difluoro- phenyl) sulfonamido)- 5-(4-(4-(4- oxopent-2- enoyl) piperazin-1-yl) quinazolin-6- yl)picolinate::US20250145589, Example 181

SMILES COC(=O)c1ncc(-c2ccc3ncnc(N4CCN(C(=O)/C=C/C(C)=O)CC4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 738376   

LigandPNGBDBM738376(methyl (E)-3- ((2,4-difluoro- phenyl) sulfonamido)...)
Affinity DataIC50: 0.730nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kα with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

LigandPNGBDBM738376(methyl (E)-3- ((2,4-difluoro- phenyl) sulfonamido)...)
Affinity DataIC50: 20.4nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kδ with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent