BDBM738379 (E)-2-chloro-5- methoxy-N-(2- methoxy-5-(4- (4-(4-oxopent- 2-enoyl) piperazin-1- yl)quinazolin- 6-yl)pyridin-3- yl)benzene- sulfonamide::US20250145589, Example 184

SMILES COc1ccc(Cl)c(S(=O)(=O)Nc2cc(-c3ccc4ncnc(N5CCN(C(=O)/C=C/C(C)=O)CC5)c4c3)cnc2OC)c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 738379   

LigandPNGBDBM738379((E)-2-chloro-5- methoxy-N-(2- methoxy-5-(4- (4-(4-...)
Affinity DataIC50: 0.810nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kα with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

LigandPNGBDBM738379((E)-2-chloro-5- methoxy-N-(2- methoxy-5-(4- (4-(4-...)
Affinity DataIC50: 16.2nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kδ with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandPNGBDBM738379((E)-2-chloro-5- methoxy-N-(2- methoxy-5-(4- (4-(4-...)
Affinity DataIC50: 365nMAssay Description:The HTRF KRASG12C/SOS1 Binding Assay was used to measure the interaction between KRASG12C and SOS1 proteins, and evaluate the enzymatic activity of c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent