BDBM738393 Preparation of (E)-2,4-difluoro-N-(2-methoxy-5-(4-(1-(4-oxopent-2-enoyl)-1,2,3,6-tetrahydropyridin-4-yl)quinazolin-6-yl)pyridin-3-yl)benzenesulfonamide::US20250145589, Example 198

SMILES COc1ncc(-c2ccc3ncnc(C4=CCN(C(=O)/C=C/C(C)=O)CC4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 738393   

LigandPNGBDBM738393(Preparation of (E)-2,4-difluoro-N-(2-methoxy-5-(4-...)
Affinity DataIC50: 1.10nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kα with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM738393(Preparation of (E)-2,4-difluoro-N-(2-methoxy-5-(4-...)
Affinity DataIC50: 13.3nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kδ with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM738393(Preparation of (E)-2,4-difluoro-N-(2-methoxy-5-(4-...)
Affinity DataIC50: 133nMAssay Description:The HTRF KRASG12C/SOS1 Binding Assay was used to measure the interaction between KRASG12C and SOS1 proteins, and evaluate the enzymatic activity of c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent