BDBM738414 (E)-2,4-trifluoro- N-(2-methoxy- 5-(4-(4-(4- oxopent-2- enoyl) piperazin-1-yl) pyrido[3,2-d] pyrimidin-6-yl) pyridin-3-yl) benzene- sulfonamide::US20250145589, Example 219

SMILES COc1ncc(-c2ccc3ncnc(N4CCN(C(=O)/C=C/C(C)=O)CC4)c3n2)cc1NS(=O)(=O)c1c(F)cc(F)cc1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 738414   

LigandPNGBDBM738414((E)-2,4-trifluoro- N-(2-methoxy- 5-(4-(4-(4- oxope...)
Affinity DataIC50: 0.910nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kα with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM738414((E)-2,4-trifluoro- N-(2-methoxy- 5-(4-(4-(4- oxope...)
Affinity DataIC50: 11.6nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kδ with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM738414((E)-2,4-trifluoro- N-(2-methoxy- 5-(4-(4-(4- oxope...)
Affinity DataIC50: 152nMAssay Description:The HTRF KRASG12C/SOS1 Binding Assay was used to measure the interaction between KRASG12C and SOS1 proteins, and evaluate the enzymatic activity of c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent