BDBM738417 (E)-N-(2- methoxy-5- (4-(4- (4-oxopent-2- enoyl)piperazin- 1-yl)pyrido[3,2- d]pyrimidin-6- yl)pyridin-3-yl)- 2,4-dimethyl- thiazole-5- sulfonamide::US20250145589, Example 222

SMILES COc1ncc(-c2ccc3ncnc(N4CCN(C(=O)/C=C/C(C)=O)CC4)c3n2)cc1NS(=O)(=O)c1sc(C)nc1C

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 738417   

LigandPNGBDBM738417((E)-N-(2- methoxy-5- (4-(4- (4-oxopent-2- enoyl)pi...)
Affinity DataIC50: 0.490nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kα with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM738417((E)-N-(2- methoxy-5- (4-(4- (4-oxopent-2- enoyl)pi...)
Affinity DataIC50: 11.7nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kδ with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent