BDBM738420 (E)-2-chloro-6- fluoro-N-(2- methoxy-5-(4- (4-(4- oxopent-2- enoyl)piperazin- 1-yl)pyrido[3,2- d]pyrimidin-6- yl)pyridin-3-yl) benzene- sulfonamide::US20250145589, Example 225

SMILES COc1ncc(-c2ccc3ncnc(N4CCN(C(=O)/C=C/C(C)=O)CC4)c3n2)cc1NS(=O)(=O)c1c(F)cccc1Cl

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 738420   

LigandPNGBDBM738420((E)-2-chloro-6- fluoro-N-(2- methoxy-5-(4- (4-(4- ...)
Affinity DataIC50: 0.5nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kα with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

LigandPNGBDBM738420((E)-2-chloro-6- fluoro-N-(2- methoxy-5-(4- (4-(4- ...)
Affinity DataIC50: 8.90nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kδ with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandPNGBDBM738420((E)-2-chloro-6- fluoro-N-(2- methoxy-5-(4- (4-(4- ...)
Affinity DataIC50: 110nMAssay Description:The HTRF KRASG12C/SOS1 Binding Assay was used to measure the interaction between KRASG12C and SOS1 proteins, and evaluate the enzymatic activity of c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent