BDBM738430 (E)-2-chloro-6- fluoro-N-(2- methoxy-5-(4- (1-(4-oxopent- 2-enoyl) piperidin-4-yl) pyrido[3,2-d] pyrimidin-6- yl)pyridin-3- yl)benzene- sulfonamide::US20250145589, Example 235

SMILES COc1ncc(-c2ccc3ncnc(C4CCN(C(=O)/C=C/C(C)=O)CC4)c3n2)cc1NS(=O)(=O)c1c(F)cccc1Cl

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 738430   

LigandPNGBDBM738430((E)-2-chloro-6- fluoro-N-(2- methoxy-5-(4- (1-(4-o...)
Affinity DataIC50: 0.300nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kα with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

LigandPNGBDBM738430((E)-2-chloro-6- fluoro-N-(2- methoxy-5-(4- (1-(4-o...)
Affinity DataIC50: 2.38nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kδ with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandPNGBDBM738430((E)-2-chloro-6- fluoro-N-(2- methoxy-5-(4- (1-(4-o...)
Affinity DataIC50: 113nMAssay Description:The HTRF KRASG12C/SOS1 Binding Assay was used to measure the interaction between KRASG12C and SOS1 proteins, and evaluate the enzymatic activity of c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent