BDBM738436 (E)-2-chloro-6- fluoro-N-(2- methoxy-5-(4-(1- (4-oxopent-2- enoyl)-1,2,3,6- tetrahydropyridin- 4-yl)pyrido[3,2-d] pyrimidin-6- yl)pyridin-3-yl) benzenesulfonamide::US20250145589, Example 241

SMILES COc1ncc(-c2ccc3ncnc(C4=CCN(C(=O)/C=C/C(C)=O)CC4)c3n2)cc1NS(=O)(=O)c1c(F)cccc1Cl

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 738436   

LigandPNGBDBM738436((E)-2-chloro-6- fluoro-N-(2- methoxy-5-(4-(1- (4-o...)
Affinity DataIC50: 0.270nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kα with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

LigandPNGBDBM738436((E)-2-chloro-6- fluoro-N-(2- methoxy-5-(4-(1- (4-o...)
Affinity DataIC50: 2.96nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kδ with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandPNGBDBM738436((E)-2-chloro-6- fluoro-N-(2- methoxy-5-(4-(1- (4-o...)
Affinity DataIC50: 454nMAssay Description:The HTRF KRASG12C/SOS1 Binding Assay was used to measure the interaction between KRASG12C and SOS1 proteins, and evaluate the enzymatic activity of c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent