BDBM738442 Preparation of (E)-2,4-difluoro-N-(2-methoxy-5-(4-(1-(4-oxopent-2-enoyl)pyrrolidin-3-yl)quinazolin-6-yl)pyridin-3-yl)benzenesulfonamide::US20250145589, Example 247

SMILES COc1ncc(-c2ccc3ncnc(C4CCN(C(=O)/C=C/C(C)=O)C4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 738442   

LigandPNGBDBM738442(Preparation of (E)-2,4-difluoro-N-(2-methoxy-5-(4-...)
Affinity DataIC50: 0.530nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kα with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM738442(Preparation of (E)-2,4-difluoro-N-(2-methoxy-5-(4-...)
Affinity DataIC50: 3.33nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kδ with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM738442(Preparation of (E)-2,4-difluoro-N-(2-methoxy-5-(4-...)
Affinity DataIC50: 277nMAssay Description:The HTRF KRASG12C/SOS1 Binding Assay was used to measure the interaction between KRASG12C and SOS1 proteins, and evaluate the enzymatic activity of c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent