BDBM739492 N-(4-((1H-pyrazol-1-yl)methyl)-2,2-difluoro-[1,3]dioxolo[4'',5'':5,6]benzo[1,2-d]isoxazol-8-yl)-2,6-dimethoxybenzenesulfonamide 5::US20250145637, Example 5

SMILES COc1cccc(OC)c1S(=O)(=O)Nc1noc2cc(Cn3cccn3)c3c(c12)OC(F)(F)O3

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 739492   

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM739492(N-(4-((1H-pyrazol-1-yl)methyl)-2,2-difluoro-[1,3]d...)
Affinity DataIC50: 1nMAssay Description:a. The prepared enzyme solution was added to a 384-well plate at 3 μL/well, and 3 μL of 1× assay buffer was added to each well in columns 23 and 24 (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

TargetHistone acetyltransferase KAT6B(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM739492(N-(4-((1H-pyrazol-1-yl)methyl)-2,2-difluoro-[1,3]d...)
Affinity DataIC50: 1.5nMAssay Description:a. 1× buffer 2: 50 mM Tris-HCl, pH 7.8; 0.1 mM EDTA; 0.01% v/v tween-20; 1 mM DTT; 0.01% m/v bovine serum albumin.b. KAT6B enzyme solution: 3 nM (fin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent