BDBM739738 (S)-1-(3-(4-amino-3-((1-ethyl-6-fluoro-1H-benzo[d]imidazol-5-yl)ethynyl)-7-(thiazol-2-yl)-1H-pyrazolo[4,3-c]pyridin-1-yl)pyrrolidin-1-yl)prop-2-en-1-one::US20250152564, Example 22

SMILES C=CC(=O)N1CC[C@H](n2nc(C#Cc3cc4ncn(CC)c4cc3F)c3c(N)ncc(-c4nccs4)c32)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 739738   

TargetFibroblast growth factor receptor 2 [V564F](Human)
Shanghai Hansoh Biomedical

US Patent
LigandPNGBDBM739738((S)-1-(3-(4-amino-3-((1-ethyl-6-fluoro-1H-benzo[d]...)
Affinity DataIC50: 0.800nMAssay Description:TR-FRET (time-resolved fluorescence resonance energy transfer) method was used to detect the inhibitory activity of the compounds on FGFR1, FGFR2, FG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/15/2025
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Shanghai Hansoh Biomedical

US Patent
LigandPNGBDBM739738((S)-1-(3-(4-amino-3-((1-ethyl-6-fluoro-1H-benzo[d]...)
Affinity DataIC50: 1.60nMAssay Description:TR-FRET (time-resolved fluorescence resonance energy transfer) method was used to detect the inhibitory activity of the compounds on FGFR1, FGFR2, FG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/15/2025
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Shanghai Hansoh Biomedical

US Patent
LigandPNGBDBM739738((S)-1-(3-(4-amino-3-((1-ethyl-6-fluoro-1H-benzo[d]...)
Affinity DataIC50: 6.5nMAssay Description:TR-FRET (time-resolved fluorescence resonance energy transfer) method was used to detect the inhibitory activity of the compounds on FGFR1, FGFR2, FG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/15/2025
Entry Details
US Patent