BDBM740589 8-methyl-3-[(3S)-tetrahydrofuran-3- yl]oxy-N-[(1R)-1-[3- (trifluoromethyl)phenyl]ethyl]pyrido[2,3- d]pyridazin-5-amine::US20250154147, Example 10

SMILES Cc3nnc(N[C@H](C)c1cccc(C(F)(F)F)c1)c4cc(O[C@H]2CCOC2)cnc34

InChI Key

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 740589   

TargetGTPase KRas/Son of sevenless homolog 1 [564-1049](Human)
Jazz Pharmaceuticals Ireland

US Patent
LigandPNGBDBM740589(8-methyl-3-[(3S)-tetrahydrofuran-3- yl]oxy-N-[(1R)...)
Affinity DataIC50: 174nMAssay Description:The capacity of compounds to inhibit SOS1 binding to KRAS-WT (wild-type) was quantified using a FRET-based protein-protein interaction assay. The ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/16/2025
Entry Details
US Patent