BDBM740594 5-methyl-2-[(3S)-tetrahydrofuran-3- yl]oxy-N-[1-[3- (trifluoromethyl)phenyl]ethyl]pyrido[2,3- d]pyridazin-8-amine::US20250154147, Example 15

SMILES Cc3nnc(NC(C)c1cccc(C(F)(F)F)c1)c4nc(O[C@H]2CCOC2)ccc34

InChI Key

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 740594   

TargetGTPase KRas/Son of sevenless homolog 1 [564-1049](Human)
Jazz Pharmaceuticals Ireland

US Patent
LigandPNGBDBM740594(5-methyl-2-[(3S)-tetrahydrofuran-3- yl]oxy-N-[1-[3...)
Affinity DataIC50: 676nMAssay Description:The capacity of compounds to inhibit SOS1 binding to KRAS-WT (wild-type) was quantified using a FRET-based protein-protein interaction assay. The ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/16/2025
Entry Details
US Patent