BDBM7425 (2 Z,3 E)-5,6-Dichloroindirubin-3 -acetoxime::6,5-dichloroindirubin-3 -acetoxime::[(3E)-2-[(3Z)-5,6-dichloro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-dihydro-1H-indol-3-ylidene]amino acetate::indirubin deriv. 8e

SMILES CC(=O)ON=C1C(Nc2ccccc12)=C1C(=O)Nc2cc(Cl)c(Cl)cc12

InChI Key InChIKey=DMFMPEWLXMKYKK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 7425   

TargetCyclin-dependent kinase 5 activator 1 [99-307](Human)
University of Athens

LigandPNGBDBM7425((2 Z,3 E)-5,6-Dichloroindirubin-3 -acetoxime | 6,5...)
Affinity DataIC50:  100nMT: 30°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
University of Athens

LigandPNGBDBM7425((2 Z,3 E)-5,6-Dichloroindirubin-3 -acetoxime | 6,5...)
Affinity DataIC50:  3.00E+4nMT: 30°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlycogen synthase kinase-3 beta(Porcine)
University of Athens

LigandPNGBDBM7425((2 Z,3 E)-5,6-Dichloroindirubin-3 -acetoxime | 6,5...)
Affinity DataIC50:  4nMT: 30°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed