BDBM743169 2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- fluorotetrahydro- 1H-pyrrolizin- 7a(5H)- yl)methoxy)-4- (3-hydroxy-3- methylazepan-1- yl)quinazolin-7- yl)-7- fluorobenzo[b] thiophene-3- carbonitrile Isomer 1::US20250163064, Example 28

SMILES CC1(O)CCCCN(c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c(F)c(-c4ccc(F)c5sc(N)c(C#N)c45)c(Cl)cc23)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 743169   

Targetkras g12d tr-fret(Human)
Amgen

US Patent
LigandPNGBDBM743169(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 3nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/19/2025
Entry Details
US Patent

Targetkras g12d coupled exchange(Human)
Amgen

US Patent
LigandPNGBDBM743169(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 5nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/19/2025
Entry Details
US Patent