BDBM743171 2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- fluorotetrahydro- 1H-pyrrolizin- 7a(5H)- yl)methoxy)-4- ((R)-6-hydroxy- 1,4-oxazepan-4- yl)quinazolin-7- yl)-7- fluorobenzo[b] thiophene-3- carbonitrile::US20250163064, Example 30

SMILES N#Cc1c(N)sc2c(F)ccc(-c3c(Cl)cc4c(N5CCOC[C@H](O)C5)nc(OC[C@@]56CCCN5C[C@H](F)C6)nc4c3F)c12

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 743171   

Targetkras g12d tr-fret(Human)TBA
LigandPNGBDBM743171(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 0.400nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM743171(2-Amino-4-(6- chloro-8-fluoro- 2-(((2R,7aS)-2- flu...)
Affinity DataIC50: 0.800nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent