BDBM743995 US12312329, Example T-3

SMILES C=CC(=O)Nc1cc(Nc2ncc(C)c(-n3cc(CN(C)C)c(-c4ccccc4)n3)n2)c(OC)nc1N1CCOCC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 743995   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM743995(US12312329, Example T-3)
Affinity DataIC50: 0.600nMAssay Description:WT EGFR and EGFR[L858R/T790M] kinase detection: In 5× kinase buffer A, WT EGFR or EGFR[L858R/T790M] kinase was mixed with different concentrations of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM743995(US12312329, Example T-3)
Affinity DataIC50: 6.29nMAssay Description:WT EGFR and EGFR[L858R/T790M] kinase detection: In 5× kinase buffer A, WT EGFR or EGFR[L858R/T790M] kinase was mixed with different concentrations of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2025
Entry Details
US Patent