BDBM744028 1-Isopropyl-N-(2-methoxy-4-(piperazin- 1-yl)phenyl)-1H-[1,2,3]triazolo[4,5-h]quin- azolin-8-amine hydrochloride::US12312355, Compound I-30

SMILES COc2cc(N1CCNCC1)ccc2Nc5ncc4ccc3nnn(C(C)C)c3c4n5

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 744028   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology

US Patent
LigandPNGBDBM744028(1-Isopropyl-N-(2-methoxy-4-(piperazin- 1-yl)phenyl...)
Affinity DataIC50: 10nMAssay Description:The inhibitory effect of the compound on the kinase CDK4/cyclin D3 was tested by the Caliper Mobility Shift Assay method. The final test concentratio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology

US Patent
LigandPNGBDBM744028(1-Isopropyl-N-(2-methoxy-4-(piperazin- 1-yl)phenyl...)
Affinity DataIC50: 10nMAssay Description:The inhibitory effect of the compound on the kinase CDK4/cyclin D3 was tested by the Caliper Mobility Shift Assay method. The final test concentratio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology

US Patent
LigandPNGBDBM744028(1-Isopropyl-N-(2-methoxy-4-(piperazin- 1-yl)phenyl...)
Affinity DataIC50: 10nMAssay Description:The inhibitory effect of the compound on the kinase CDK4/cyclin D3 was tested by the Caliper Mobility Shift Assay method. The final test concentratio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2025
Entry Details
US Patent