BDBM744652 (5S)-5-methyl-6-[4-{[(1H-pyrazol-5-yl)methyl]amino}-3-(trifluoromethyl)phenyl]-4,5-dihydro-1,2,4-triazin-3(2H)-one::US20250170136, Example 2

SMILES C[C@@H]1NC(=O)NN=C1c1ccc(NCc2ccn[nH]2)c(C(F)(F)F)c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 744652   

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM744652((5S)-5-methyl-6-[4-{[(1H-pyrazol-5-yl)methyl]amino...)
Affinity DataIC50: 5nMAssay Description:For the determination of the in vitro effect of example compounds on the PDE3A reactions 2 μl of the respective example compound solution in DMSO (se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2025
Entry Details
US Patent

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM744652((5S)-5-methyl-6-[4-{[(1H-pyrazol-5-yl)methyl]amino...)
Affinity DataIC50: 6nMAssay Description:The commercially available 3H-cAMP Scintillation Proximity Assay (SPA, Perkin Elmer) system was used for enzyme inhibition studies. For the determina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2025
Entry Details
US Patent