BDBM745153 4-(6,7-difluoro-3-quinolylamino)- 2-[4-(3,3-dimethyl-4-methyl-1- piperazinyl)-3- anisidino]pyrimidine::US20250171431, Compound 470

SMILES COc1cc(Nc2nccc(Nc3cnc4cc(F)c(F)cc4c3)n2)ccc1N1CCN(C)C(C)(C)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 745153   

TargetInsulin-like growth factor 1 receptor(Human)
Horizon Therapeutics Ireland Dac

US Patent
LigandPNGBDBM745153(4-(6,7-difluoro-3-quinolylamino)- 2-[4-(3,3-dimeth...)
Affinity DataIC50: 500nMAssay Description:The media was removed and replaced by 50 μL of 1× lysis buffer from the AlphaLISA kit (with 1× of cOmplete™ protease inhibitor). The plates were seal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2025
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Horizon Therapeutics Ireland Dac

US Patent
LigandPNGBDBM745153(4-(6,7-difluoro-3-quinolylamino)- 2-[4-(3,3-dimeth...)
Affinity DataIC50: 1.25E+3nMAssay Description:The media was removed and replaced by 50 μL of 1× lysis buffer from the AlphaLISA kit (with 1× of cOmplete™ protease inhibitor). The plates were seal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2025
Entry Details
US Patent