BDBM745274 2-{3-[5-(2- aminopropan-2- yl)-3- chloropyridin-2- yl]cyclobutyl}-7- methoxy[1,2,4] triazolo[1,5- c]quinazolin-5- amine::US20250171447, Ex-87

SMILES COc1cccc2c1nc(N)n1nc(C3CC(c4ncc(C(C)(C)N)cc4Cl)C3)nc21

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 745274   

TargetAdenosine receptor A2a(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM745274(2-{3-[5-(2- aminopropan-2- yl)-3- chloropyridin-2-...)
Affinity DataIC50: 0.800nMAssay Description:Binding affinity using SPA was conducted as follows. Test compounds (50 μL) were dispensed into individual wells of a 384-well OptiPlate™ well (Perki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2025
Entry Details
US Patent

TargetAdenosine receptor A2b(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM745274(2-{3-[5-(2- aminopropan-2- yl)-3- chloropyridin-2-...)
Affinity DataIC50: 2.70nMAssay Description:To perform the assay, compounds of the invention to be tested were first solubilized in 100% DMSO and further diluted in 100% DMSO to generate, typic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2025
Entry Details
US Patent