BDBM746068 5-chloro-1-(1-(4-(difluoromethyl)-5-fluoropyrimidin-2-yl)-1H-pyrazol-4-yl)-6-(4-(3-methyloxetan-3-yl)piperazin-1-yl)-1H-indazole::US12319671, Example 5.21

SMILES CC1(N2CCN(c3cc4c(cnn4-c4cnn(-c5ncc(F)c(C(F)F)n5)c4)cc3Cl)CC2)COC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 746068   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM746068(5-chloro-1-(1-(4-(difluoromethyl)-5-fluoropyrimidi...)
Affinity DataIC50: 625nMAssay Description:Assays were performed in the presence of 134 μM ATP (Km ATP). Upon completion, the assay was stopped, and phosphorylated substrate detected with a te...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/25/2025
Entry Details
US Patent