BDBM746168 1-(1- (bicyclo[1.1.1]pentan-1- yl)-1H-pyrazol-4-yl)-5- chloro-6-(4-(3- methyloxetan-3- yl)piperazin-1-yl)-1H- indazole::US12319671, Example 7.13

SMILES CC1(N2CCN(c3cc4c(cnn4-c4cnn(C56CC(C5)C6)c4)cc3Cl)CC2)COC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 746168   

LigandPNGBDBM746168(1-(1- (bicyclo[1.1.1]pentan-1- yl)-1H-pyrazol-4-yl...)
Affinity DataIC50: 8nMAssay Description:Inhibition of LRRK2 in human PBMCs assessed as Ser935 dephosphorylation incubated for 90 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM746168(1-(1- (bicyclo[1.1.1]pentan-1- yl)-1H-pyrazol-4-yl...)
Affinity DataIC50: 625nMAssay Description:Assays were performed in the presence of 134 μM ATP (Km ATP). Upon completion, the assay was stopped, and phosphorylated substrate detected with a te...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/25/2025
Entry Details
US Patent