BDBM746188 (3R.4R or 3S,4S)-4- (4-{5-chloro-1-[1-(3- {[(~2~H_3_)methyl- oxy]methyl}bicyclo [1.1.1]pentan-1-yl)-1H- pyrazol-4-yl]-1H- indazol-6- yl}piperazin-1-yl)-4- methyloxolan-3-ol::US12319671, Example 12.5

SMILES [2H]C([2H])([2H])OCC12CC(n3cc(-n4ncc5cc(Cl)c(N6CCN([C@]7(C)COC[C@@H]7O)CC6)cc54)cn3)(C1)C2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 746188   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM746188((3R.4R or 3S,4S)-4- (4-{5-chloro-1-[1-(3- {[(~2~H_...)
Affinity DataIC50: 157nMAssay Description:Assays were performed in the presence of 134 μM ATP (Km ATP). Upon completion, the assay was stopped, and phosphorylated substrate detected with a te...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/25/2025
Entry Details
US Patent