BDBM746217 (1R,5S,8r)-3-{1-[1- (bicyclo[1.1.1]pentan-1- yl)-1H-pyrazol-4-yl]-5- chloro-1H-pyrazolo[3,4- b]pyridin-6-yl}-8-methyl- 3-azabicyclo[3.2.1]octan- 8-ol::US12319671, Example 20.5

SMILES CC1(O)C2CCC1CN(c1cc3c(cnn3-c3cnn(C45CC(C4)C5)c3)cc1Cl)C2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 746217   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM746217((1R,5S,8r)-3-{1-[1- (bicyclo[1.1.1]pentan-1- yl)-1...)
Affinity DataIC50: 625nMAssay Description:Assays were performed in the presence of 134 μM ATP (Km ATP). Upon completion, the assay was stopped, and phosphorylated substrate detected with a te...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/25/2025
Entry Details
US Patent