BDBM747173 (6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)(5- methylpyrimidin-2-yl)methanone::US20250179079, Compound 12

SMILES Cc1cnc(C(=O)N2CCc3[nH]c4c(Cl)c(Cl)ccc4c3C2)nc1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 747173   

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 747173BDBM747173((6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]i...)
Affinity DataIC50: 510nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 747173BDBM747173((6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]i...)
Affinity DataIC50: 513nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent