BDBM747227 (S)-1-(7,8-dichloro-1-methyl-3,4-dihydropyrazino[1,2-b]indazol-2(1H)-yl)-2- hydroxyethan-1-one::US20250179079, Compound 60B::WO2023015728, Compound 60B
SMILES C[C@H]1c2c3ccc(Cl)c(Cl)c3nn2CCN1C(=O)CO
InChI Key InChIKey=TWOXJOKQZBXDKW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 747227
Affinity DataIC50: 35nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Affinity DataIC50: 82.8nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Affinity DataIC50: 82.8nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair