BDBM753991 2-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octa-3-yl)-8-fluoro-2-((tetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-[1,1'-biphenyl]-4-ol::US20250206759, Example 24

SMILES Oc1ccc(-c2ccccc2)c(-c2ncc3c(N4CC5CCC(C4)N5)nc(OCC45CCCN4CCC5)nc3c2F)c1

InChI Key InChIKey=GVZXRLAIZZLKOJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 753991   

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chengdu Hyperway Pharmaceuticals

US Patent
LigandPNGBDBM753991(2-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octa-3-yl)-8-...)
Affinity DataIC50: 1.00E+3nMAssay Description:In a 384-well reaction plate (Corning, CLS4514), 0.1 microliter of the compound was added. After centrifugation, a mixture of 5 microliters of Tag2-K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/20/2025
Entry Details
Go to US Patent