BDBM75484 US20250382297, Example 39
SMILES C=C(F)C(=O)Nc1ccc(-c2c(-c3ccc(Oc4nccc(C)n4)cc3)c(C(N)=O)c3cnc(C)cn23)cc1
InChI Key InChIKey=QOTHEKIYUNNSPZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 33 hits for monomerid = 75484
Affinity DataIC50: 0.110nMAssay Description:Inhibition of FGFR2 V564F mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of wild type FGFR2 (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Inhibition of FGFR2 V564I mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70nMAssay Description:Inhibition of FGFR2 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 60 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of FGFR2 E565G mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 5.40nMAssay Description:Inhibition of FGFR2 K641R mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 7.20nMAssay Description:Inhibition of FGFR3 V555L mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 7.80nMAssay Description:Inhibition of FGFR2 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 120 mins followed by substrate addition in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 8.60nMAssay Description:Inhibition of FGFR2 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 90 mins followed by substrate addition in presence of K...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of FGFR2 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 60 mins followed by substrate addition in presence of K...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of wild type FGFR3 (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of FGFR3 V555M mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of FGFR2 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 30 mins followed by substrate addition in presence of K...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of FGFR3 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 60 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of FGFR2 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 10 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of FGFR3 K650E mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Inhibition of FGFR3 K650M mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 49nMAssay Description:Inhibition of FGFR2 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 15 mins followed by substrate addition in presence of K...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...More data for this Ligand-Target Pair
Affinity DataKi: 57nMAssay Description:Binding affinity to FGFR2 (unknown origin) assessed as inhibition constant by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 85nMAssay Description:Inhibition of FGFR3 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 10 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 85nMAssay Description:Inhibition of FGFR2 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 10 mins followed by substrate addition in presence of K...More data for this Ligand-Target Pair
Affinity DataIC50: 116nMAssay Description:Inhibition of FGFR2 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 5 mins followed by substrate addition in presence of Km...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of FGFR1 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 60 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...More data for this Ligand-Target Pair
Affinity DataKi: 1.27E+3nMAssay Description:Binding affinity to FGFR3 (unknown origin) assessed as inhibition constant by HTRF methodMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Insilico Medicine Shanghai Ltd
Curated by ChEMBL
Insilico Medicine Shanghai Ltd
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of wild type human partial length FLT3 (V592 to Y969 residues) expressed in bacterial expression system by Kinome scan methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.28E+3nMAssay Description:Inhibition of FGFR1 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 10 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 3.35E+3nMAssay Description:Inhibition of FGFR4 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 60 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 4.82E+3nMAssay Description:Inhibition of wild type human partial length Aurora C (E122 to K401 residues) expressed in mammalian expression system by Kinome scan methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Insilico Medicine Shanghai Ltd
Curated by ChEMBL
Insilico Medicine Shanghai Ltd
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild type human partial length KDR (R787 to P1253 residues) expressed in mammalian expression system by Kinome scan methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Human)
Insilico Medicine Shanghai Ltd
Curated by ChEMBL
Insilico Medicine Shanghai Ltd
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild type human partial length FLT1 (R781 to F1239) expressed in mammalian expression system by Kinome scan methodMore data for this Ligand-Target Pair