BDBM757322 US12357603, Example 14
SMILES CN(C)c1ccc2cc(C(=O)NS(=O)(=O)c3ccccc3-c3ccccc3)oc2c1
InChI Key InChIKey=ZUWIDJYXRPTMQW-UHFFFAOYSA-N
Data 13 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 757322
TargetHistone Acetyltransferase KAT6A [194-810]/Zinc Finger Protein Neuro-d4 (DPF1)/ Histone Acetyltransferase Type B Catalytic Subunit (HAT1)(Homo sapiens (Human))
Bayer Aktiengesellschaft
US Patent
Bayer Aktiengesellschaft
US Patent
Affinity DataIC50: 67.6nMAssay Description:Recombinant human His-tagged Kat6a protein (amino acids 194-810), was purified in-house from Baculovirus-infected insect cells (Sf9). Histone H4 pept...More data for this Ligand-Target Pair
Affinity DataIC50: 71nMAssay Description:Inhibition of his-tagged human recombinant KAT6A (194 to 810 residues) expressed in baculovirus-infected Sf9 insect cells using H4-derived peptide as...More data for this Ligand-Target Pair
Affinity DataIC50: 71nMAssay Description:Inhibition of KAT6A (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 83nMAssay Description:Inhibition of C-terminal human recombinant KAT6B (431 to end residues) expressed in baculovirus-infected Sf9 insect cells using H4-derived peptide as...More data for this Ligand-Target Pair
Affinity DataIC50: 83nMAssay Description:Inhibition of KAT6B (unknown origin)More data for this Ligand-Target Pair
TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))
Bayer Aktiengesellschaft
US Patent
Bayer Aktiengesellschaft
US Patent
Affinity DataIC50: 83.3nMAssay Description:Kat6b was incubated for 30 mins at 22° C. in the presence of different concentrations of test substances (0 μM, and within the range 0.01-20 μM) in a...More data for this Ligand-Target Pair
Affinity DataIC50: 168nMAssay Description:Inhibition of KAT6A in human MVLN cells assessed as decrease in estrogen receptor level incubated for 24 hrs by gene reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 168nMAssay Description:Inhibition of KAT6A in human MVLN cells assessed as decrease in estrogen receptor level incubated for 24 hrs by gene reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 670nMAssay Description:Inhibition of KAT6A in human ZR-75-1 cells assessed as reduction in H3K23ac level measured for 24 hrs by HTRF analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant KAT7 expressed in Sf9 insect cells using H4-derived peptide as substrate incubated ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged human recombinant p300 (965 to 1810 residues) expressed in Sf9 insect cells using H3-derived peptide as substrate incubated ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant KAT8 (174 to 449 residues) using H4-derived peptide as substrate incubated for 60 m...More data for this Ligand-Target Pair
Affinity DataIC50: 1.43E+4nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant KAT5 expressed in Sf9 insect cells using H4-derived peptide as substrate incubated ...More data for this Ligand-Target Pair