BDBM757373 6-Amino-N-([1,1'-biphenyl]-2-sulfonyl)-1-benzofuran-2-carboxamide::US12357603, Example 42

SMILES Nc1ccc2cc(C(=O)NS(=O)(=O)c3ccccc3-c3ccccc3)oc2c1

InChI Key InChIKey=ZTUOMJZTHSMGHJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 757373   

LigandChemical structure of BindingDB Monomer ID 757373BDBM757373(6-Amino-N-([1,1'-biphenyl]-2-sulfonyl)-1-benzofura...)
Affinity DataIC50: 1.07E+3nMAssay Description:Recombinant human His-tagged Kat6a protein (amino acids 194-810), was purified in-house from Baculovirus-infected insect cells (Sf9). Histone H4 pept...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/28/2025
Entry Details
US Patent

TargetHistone acetyltransferase KAT6A(Human)
Bayer AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 757373BDBM757373(6-Amino-N-([1,1'-biphenyl]-2-sulfonyl)-1-benzofura...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of his-tagged human recombinant KAT6A (194 to 810 residues) expressed in baculovirus-infected Sf9 insect cells using H4-derived peptide as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 757373BDBM757373(6-Amino-N-([1,1'-biphenyl]-2-sulfonyl)-1-benzofura...)
Affinity DataIC50: 3.59E+3nMAssay Description:Kat6b was incubated for 30 mins at 22° C. in the presence of different concentrations of test substances (0 μM, and within the range 0.01-20 μM) in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/28/2025
Entry Details
US Patent