BDBM764933 3-((4,4-difluorocyclohexyl)(ethyl) amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(trans-3-(cis-2,6-dimethylmorpholinyl)cyclobutoxy)-2-methylbenzamide::US12390472, Example 45

SMILES CCN(c1cc(O[C@H]2C[C@H](N3C[C@@H](C)O[C@@H](C)C3)C2)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1CCC(F)(F)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 764933   

LigandPNGBDBM764933(3-((4,4-difluorocyclohexyl)(ethyl) amino)-N-((4,6-...)
Affinity DataIC50: 2.30nMAssay Description:Table 1: Test ConditionsEZH2 enzyme complex: 25 ng/uLHistone H3 peptide substrate: 4 uMSAM: 2 uMReaction time: 300 minProcedures1. Each compound disc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM764933(3-((4,4-difluorocyclohexyl)(ethyl) amino)-N-((4,6-...)
Affinity DataIC50: 3nMAssay Description:Table 4: ProceduresCompounds at different concentrations were dissolved in 100% DMSO and transferred to test plates, and the final concentration of D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM764933(3-((4,4-difluorocyclohexyl)(ethyl) amino)-N-((4,6-...)
Affinity DataIC50: 5.20nMAssay Description:ProceduresCompounds at different concentrations were dissolved in 100% DMSO and transferred to test plates, and the final concentration of DMSO was 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM764933(3-((4,4-difluorocyclohexyl)(ethyl) amino)-N-((4,6-...)
Affinity DataIC50: 55nMAssay Description:Table 1: Test ConditionsEZH2 enzyme complex: 25 ng/uLHistone H3 peptide substrate: 4 uMSAM: 2 uMReaction time: 300 minProcedures1. Each compound disc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent