BDBM764968 WO2012142513, Compound 194::tert-butyl 3-(3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methylphenoxy)azetidine-1-carboxylate::US12390472, Example EPZ194

SMILES CCN(c1cc(OC2CN(C(=O)OC(C)(C)C)C2)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1CCOCC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 764968   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Evopoint Biosciences

US Patent
LigandPNGBDBM764968(WO2012142513, Compound 194 | tert-butyl 3-(3-(((4,...)
Affinity DataIC50: 1.30nMAssay Description:Table 1: Test ConditionsEZH2 enzyme complex: 25 ng/uLHistone H3 peptide substrate: 4 uMSAM: 2 uMReaction time: 300 minProcedures1. Each compound disc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Human)
Evopoint Biosciences

US Patent
LigandPNGBDBM764968(WO2012142513, Compound 194 | tert-butyl 3-(3-(((4,...)
Affinity DataIC50: 2nMAssay Description:Table 4: ProceduresCompounds at different concentrations were dissolved in 100% DMSO and transferred to test plates, and the final concentration of D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641N]()
Evopoint Biosciences

US Patent
LigandPNGBDBM764968(WO2012142513, Compound 194 | tert-butyl 3-(3-(((4,...)
Affinity DataIC50: 3.40nMAssay Description:ProceduresCompounds at different concentrations were dissolved in 100% DMSO and transferred to test plates, and the final concentration of DMSO was 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent