BDBM764969 WO2012142513, Compound 195::5-(azetidin-3-yloxy)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide::US12390472, Example EPZ195

SMILES CCN(c1cc(OC2CNC2)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1CCOCC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 764969   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Evopoint Biosciences

US Patent
LigandPNGBDBM764969(WO2012142513, Compound 195 | 5-(azetidin-3-yloxy)-...)
Affinity DataIC50: 1.90nMAssay Description:Table 1: Test ConditionsEZH2 enzyme complex: 25 ng/uLHistone H3 peptide substrate: 4 uMSAM: 2 uMReaction time: 300 minProcedures1. Each compound disc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641N]()
Evopoint Biosciences

US Patent
LigandPNGBDBM764969(WO2012142513, Compound 195 | 5-(azetidin-3-yloxy)-...)
Affinity DataIC50: 3.70nMAssay Description:ProceduresCompounds at different concentrations were dissolved in 100% DMSO and transferred to test plates, and the final concentration of DMSO was 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Human)
Evopoint Biosciences

US Patent
LigandPNGBDBM764969(WO2012142513, Compound 195 | 5-(azetidin-3-yloxy)-...)
Affinity DataIC50: 4.90nMAssay Description:Table 4: ProceduresCompounds at different concentrations were dissolved in 100% DMSO and transferred to test plates, and the final concentration of D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent