BDBM764972 3-((4,4-difluorocyclohexyl)(ethyl)amino)-5-(trans-3-(cis-2,6-dimethylmorpholino)cyclobutoxy)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide::US12390472, Example 87

SMILES CCN(c1cc(O[C@H]2C[C@H](N3C[C@@H](C)O[C@@H](C)C3)C2)cc(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C)C1CCC(F)(F)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 764972   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Evopoint Biosciences

US Patent
LigandPNGBDBM764972(3-((4,4-difluorocyclohexyl)(ethyl)amino)-5-(trans-...)
Affinity DataIC50: 1.20nMAssay Description:Table 1: Test ConditionsEZH2 enzyme complex: 25 ng/uLHistone H3 peptide substrate: 4 uMSAM: 2 uMReaction time: 300 minProcedures1. Each compound disc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641N]()
Evopoint Biosciences

US Patent
LigandPNGBDBM764972(3-((4,4-difluorocyclohexyl)(ethyl)amino)-5-(trans-...)
Affinity DataIC50: 2.60nMAssay Description:ProceduresCompounds at different concentrations were dissolved in 100% DMSO and transferred to test plates, and the final concentration of DMSO was 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Human)
Evopoint Biosciences

US Patent
LigandPNGBDBM764972(3-((4,4-difluorocyclohexyl)(ethyl)amino)-5-(trans-...)
Affinity DataIC50: 5.5nMAssay Description:Table 4: ProceduresCompounds at different concentrations were dissolved in 100% DMSO and transferred to test plates, and the final concentration of D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent