BDBM768419 (2E)-4-(dimethylamino)- 1-(2-{4-[(3-methyl-4- {[1,2,4]triazolo[1,5- a]pyridin-7- yloxy}phenyl)amino] pyrrolo[2,1-f][1,2,4]triazin- 5-yl}-2,6- diazaspiro[3.4]octan-6- yl)but-2-en-1-one::US20250276983, Example 156

SMILES Cc1cc(Nc2ncnn3ccc(N4CC5(CCN(C(=O)/C=C/CN(C)C)C5)C4)c23)ccc1Oc1ccn2ncnc2c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 768419   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM768419((2E)-4-(dimethylamino)- 1-(2-{4-[(3-methyl-4- {[1,...)
Affinity DataIC50: 200nMAssay Description:The radioactive signal generated from the aliquot of buffer solution was proportional to the amount of radiolabeled substrate produced, and which is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/15/2025
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM768419((2E)-4-(dimethylamino)- 1-(2-{4-[(3-methyl-4- {[1,...)
Affinity DataIC50: 200nMAssay Description:The radioactive signal generated from the aliquot of buffer solution was proportional to the amount of radiolabeled substrate produced, and which is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/15/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM768419((2E)-4-(dimethylamino)- 1-(2-{4-[(3-methyl-4- {[1,...)
Affinity DataIC50: 1.00E+3nMAssay Description:The radioactive signal generated from the aliquot of buffer solution was proportional to the amount of radiolabeled substrate produced, and which is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/15/2025
Entry Details
US Patent