BDBM770824 2-(6-(4-(1H-pyrrolo[2,3-c]pyridine-7-carbonyl)piperazin-1-yl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)-N-(2-chloro-4-(trifluoromethyl)phenyl)acetamide::WO2025049746, Example 45::US20260015358, Example 61

SMILES CCc1c(N2CCN(C(=O)c3nccc4cc[nH]c34)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 770824   

TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN(Human)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 770824BDBM770824(2-(6-(4-(1H-pyrrolo[2,3-c]pyridine-7-carbonyl)pipe...)
Affinity DataIC50: 32nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 770824BDBM770824(2-(6-(4-(1H-pyrrolo[2,3-c]pyridine-7-carbonyl)pipe...)
Affinity DataIC50: 35.9nMAssay Description:WRN helicase core (8xHis-tev-WRN (480-1251)) was expressed in Sf9 insect cells and purified using HiTrap TALON affinity purification followed by hepa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025049746

TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN(Human)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 770824BDBM770824(2-(6-(4-(1H-pyrrolo[2,3-c]pyridine-7-carbonyl)pipe...)
Affinity DataIC50: 67.8nMAssay Description:ATPase activity was measured using the ADP-Glo Kinase Assay following the manufacturers recommended protocol. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025049746

TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN(Human)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 770824BDBM770824(2-(6-(4-(1H-pyrrolo[2,3-c]pyridine-7-carbonyl)pipe...)
Affinity DataIC50: 100nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2026
Entry Details US Patent