BDBM771616 US20250092044, Comparative Example C

SMILES Cn1cc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(cnn3C)c2)n([C@H]2CC[C@@H](CC#N)CC2)c(=O)n4C)cn1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 771616   

LigandPNGBDBM771616(US20250092044, Comparative Example C)
Affinity DataIC50: 10nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/31/2025
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Incyte

US Patent
LigandPNGBDBM771616(US20250092044, Comparative Example C)
Affinity DataIC50: 25nMAssay Description:The kinase assays were carried out at room temperature in assay buffer (HEPES 50 mM, pH 7.0, NaN3 0.02%, BSA 0.01%, Orthovanadate 0.1 mM, DTT 1 mM, M...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/31/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Incyte

US Patent
LigandPNGBDBM771616(US20250092044, Comparative Example C)
Affinity DataIC50: 25nMAssay Description:The kinase assays were carried out at 24° C. temperature in assay buffer (HEPES 50 mM, pH 7.0, NaN3 0.02%, BSA 0.01%, Orthovanadate 0.1 mM, DTT 1 mM,...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/31/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [826-1132](Human)
Incyte

US Patent
LigandPNGBDBM771616(US20250092044, Comparative Example C)
Affinity DataIC50: 55nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/31/2025
Entry Details
US Patent