BDBM771620 US20250092044, Comparative Example G

SMILES CCn1c(=O)n(C2CCCC2)c2c3cc(-c4ccc(CN5CCC(S(C)(=O)=O)CC5)cc4)[nH]c3ncc21

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 771620   

TargetTyrosine-protein kinase JAK2 [826-1132](Human)
Incyte

US Patent
LigandPNGBDBM771620(US20250092044, Comparative Example G)
Affinity DataIC50: 300nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/31/2025
Entry Details
US Patent

LigandPNGBDBM771620(US20250092044, Comparative Example G)
Affinity DataIC50: 1.00E+3nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/31/2025
Entry Details
US Patent