BDBM771651 Methyl ((1R,3R)-3- (7-(4-((bis(methyl- d3)amino)methyl)phe- nyl)-8-(1,1- dimethyl-1,3- dihydroisobenzofuran- 5-yl)-3-(methyl- d3)-2-oxo-3,6- dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-1(2H)- yl)cyclopentyl)carba- mate::US20250092044, Example 29
SMILES [2H]C([2H])([2H])N(Cc1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc3c(c2)COC3(C)C)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C([2H])([2H])[2H])cc1)C([2H])([2H])[2H]
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 771651
Affinity DataIC50: 10nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 750nMAssay Description:The kinase assays were carried out at room temperature in assay buffer (HEPES 50 mM, pH 7.0, NaN3 0.02%, BSA 0.01%, Orthovanadate 0.1 mM, DTT 1 mM, M...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 1.00E+3nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 1.88E+3nMAssay Description:The kinase assays were carried out at 24° C. temperature in assay buffer (HEPES 50 mM, pH 7.0, NaN3 0.02%, BSA 0.01%, Orthovanadate 0.1 mM, DTT 1 mM,...More data for this Ligand-Target Pair
Ligand Info