BDBM771770 11-chloro-3,5-difluoro-10-hydroxy-19-oxa-8lambda6-thia-7,15-diazatetracyclo[18.3.1.12,6.19,13]hexacosa-1(23),2(26),3,5,9(25),10,12,20(24),21-nonaene-8,8,14-trione ::US20250289793, Compound 5

SMILES O=C1NCCCOc2cccc(c2)-c2cc(c(F)cc2F)NS(=O)(=O)c2cc1cc(Cl)c2O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 771770   

TargetATP-citrate synthase(Human)
Esperion Therapeutics

US Patent
LigandPNGBDBM771770(11-chloro-3,5-difluoro-10-hydroxy-19-oxa-8lambda6-...)
Affinity DataIC50: 5.5nMAssay Description:Table 3: Test compounds were 3-fold serially diluted in DMSO over 11-point concentration range and dispensed onto a 384-well plate. Recombinant human...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/2/2026
Entry Details
US Patent

TargetATP-citrate synthase(Human)
Esperion Therapeutics

US Patent
LigandPNGBDBM771770(11-chloro-3,5-difluoro-10-hydroxy-19-oxa-8lambda6-...)
Affinity DataIC50: 5.05E+3nMAssay Description:Table 2: Compounds of the disclosure were evaluated for their efficacy in inhibiting hACLY using rapid fire mass spectrometry (RF/MS). The final reac...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/2/2026
Entry Details
US Patent