BDBM771783 5,15-dichloro-21,23-difluoro-16-hydroxy-8,11-dioxa-18lambda6-thia-19-azatetracyclo[18.3.1.113,17.02,7]pentacosa-1(24),2,4,6,13,15,17(25),20,22-nonaene-12,18,18-trione ::US20250289793, Compound 18

SMILES O=C1OCCOc2cc(Cl)ccc2-c2cc(c(F)cc2F)NS(=O)(=O)c2cc1cc(Cl)c2O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 771783   

TargetATP-citrate synthase(Human)
Esperion Therapeutics

US Patent
LigandPNGBDBM771783(5,15-dichloro-21,23-difluoro-16-hydroxy-8,11-dioxa...)
Affinity DataIC50: 5.5nMAssay Description:Table 3: Test compounds were 3-fold serially diluted in DMSO over 11-point concentration range and dispensed onto a 384-well plate. Recombinant human...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/2/2026
Entry Details
US Patent

TargetATP-citrate synthase(Human)
Esperion Therapeutics

US Patent
LigandPNGBDBM771783(5,15-dichloro-21,23-difluoro-16-hydroxy-8,11-dioxa...)
Affinity DataIC50: 60nMAssay Description:Table 2: Compounds of the disclosure were evaluated for their efficacy in inhibiting hACLY using rapid fire mass spectrometry (RF/MS). The final reac...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/2/2026
Entry Details
US Patent