BDBM772159 US20250289807, Example 23

SMILES O=C(c1cc2c(s1)CN(c1nccc(Nc3ccc(-c4cnc[nH]4)cc3)n1)CC2)N1CC2C(C1)C2(F)F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 772159   

TargetRho-associated protein kinase 2(Human)
Graviton Bioscience

US Patent
LigandPNGBDBM772159(US20250289807, Example 23)
Affinity DataIC50: 334nMAssay Description:Each plate contained a positive control (1 μM Comp. A for ROCK2 and 1 μM RKI-1447 for ROCK1); a vehicle control (1% DMSO); a blank control (kinase re...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/4/2026
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Graviton Bioscience

US Patent
LigandPNGBDBM772159(US20250289807, Example 23)
Affinity DataIC50: 8.91E+3nMAssay Description:Each plate contained a positive control (1 μM Comp. A for ROCK2 and 1 μM RKI-1447 for ROCK1); a vehicle control (1% DMSO); a blank control (kinase re...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/4/2026
Entry Details
US Patent