BDBM772162 US20250289807, Example 22

SMILES O=C(c1nc2ccc(-c3nccc(Nc4ccc(-c5cn[nH]n5)cc4)n3)cc2[nH]1)N1CC(F)(F)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 772162   

TargetRho-associated protein kinase 2(Human)
Graviton Bioscience

US Patent
LigandPNGBDBM772162(US20250289807, Example 22)
Affinity DataIC50: 827nMAssay Description:Each plate contained a positive control (1 μM Comp. A for ROCK2 and 1 μM RKI-1447 for ROCK1); a vehicle control (1% DMSO); a blank control (kinase re...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/4/2026
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Graviton Bioscience

US Patent
LigandPNGBDBM772162(US20250289807, Example 22)
Affinity DataIC50: 2.52E+4nMAssay Description:Each plate contained a positive control (1 μM Comp. A for ROCK2 and 1 μM RKI-1447 for ROCK1); a vehicle control (1% DMSO); a blank control (kinase re...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/4/2026
Entry Details
US Patent