BDBM774077 US12428423, Compound I-60

SMILES c1cc(Nc2ncc3ccc4ncn(C5CCCC5)c4c3n2)ncc1N1CCOCC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 774077   

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM774077(US12428423, Compound I-60)
Affinity DataIC50: 6nMAssay Description:First, 10 ng of recombinant CDK4/cyclin D1 (Life Technologies PV4204) was diluted in a kinase buffer (20 mM Tris pH7.5, 10 mM MgCl2, 0.01% NP-40, 2 m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/14/2026
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM774077(US12428423, Compound I-60)
Affinity DataIC50: 6nMAssay Description:First, 10 ng of recombinant CDK4/cyclin D1 (Life Technologies PV4204) was diluted in a kinase buffer (20 mM Tris pH7.5, 10 mM MgCl2, 0.01% NP-40, 2 m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/14/2026
Entry Details
US Patent